- Title
- Antibiotics, passive smoking, high socioeconomic status and sweetened foods contribute to the risk of paediatric inflammatory bowel disease: A systematic review with meta-analysis
- Creator
- Thacker, Nisha; Duncanson, Kerith; Eslick, Guy D.; Dutt, Shoma; O'Loughlin, Edward V.; Hoedt, Emily C.; Collins, Clare E.
- Relation
- Journal of Pediatric Gastroenterogy and Nutrition Vol. 79, Issue 3, p. 610-621
- Publisher Link
- http://dx.doi.org/10.1002/jpn3.12303
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2024
- Description
- Objective: Genetic and environmental factors influence pathogenesis and rising incidence of paediatric inflammatory bowel disease (PIBD). The aim was to meta-analyse evidence of diet and environmental factors in PIBD. Methods: A systematic search was conducted to identify diet and environmental factors with comparable risk outcome measures and had been reported in two or more PIBD studies for inclusion in meta-analyses. Those with ≥2 PIBD risk estimates were combined to provide pooled risk estimates. Results: Of 4763 studies identified, 36 studies were included. PIBD was associated with higher risk with exposure to ≥/=4 antibiotic courses (includes prescriptions/purchases/courses), passive smoking, not being breastfed, sugary drink intake, being a non-Caucasian child living in a high-income country and infection history (odds ratio [OR] range: 2-3.8). Paediatric Crohn's disease (CD) was associated with higher risk with exposure to antibiotics during early childhood, ≥/=4 antibiotic courses, high socioeconomic status (SES), maternal smoking, history of atopic conditions and infection history (OR range: 1.6-4.4). A history of infection was also associated with higher risk of paediatric ulcerative colitis (UC) (OR: 3.73). Having a higher number of siblings (≥2) was associated with lower risk of paediatric CD (OR: 0.6) and paediatric UC (OR: 0.7). Pet exposure was associated with lower risk of paediatric UC (OR: 0.5). Conclusion: Several factors associated with PIBD risk were identified that could potentially be used to develop a disease screening tool. Future research is needed to address risk reduction in PIBD.
- Subject
- diet; environmental factors; inflammatory bowel disease; paediatric
- Identifier
- http://hdl.handle.net/1959.13/1510353
- Identifier
- uon:56394
- Identifier
- ISSN:0277-2116
- Rights
- x
- Language
- eng
- Reviewed
- Hits: 1454
- Visitors: 1448
- Downloads: 0